FIGURE

Figure 8

ID

ZDB-FIG-210822-15

Publication

Holmgren et al., 2021 - Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line

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Figure 8

Figure 8. PSDs are enlarged in mpv17^a9/a9 neuromasts but do not significantly change upon mechanical overstimulation. (A–D) Maximum-intensity projections of confocal images of WT (A,B) and mpv17^a9/a9 (C,D) neuromasts, either unexposed (A–C) or exposed to strong water current (B,D). (E) Quantification of presynaptic ribbon volume relative to unexposed WT control. n = 1013–1087 presynaptic particles; N = 7 experimental trials. (F) Quantification of PSD volume relative to WT control. PSDs are enlarged in unexposed mpv17^a9/a9 neuromasts and mechanically overstimulated WT neuromasts, but there is no significant change in PSD size in mechanically overstimulated mpv17^a9/a9 neuromasts (****P < 0.0001 WT exposed; *P = 0.0100 mpv17^a9/a9 control). n = 486–683 PSD particles from neuromasts L3, L4, and L5; N = 5 experimental trials. Scale bar: 5 μm. Whiskers: min. to max. values; “+” indicates mean value. “ns” = not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.