ZFIN Image: Holmgren et al., 2021, Figure 4

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Figure Caption

Figure 4

mpv17^a9/a9 larvae are more sensitive to neomycin-induced hair-cell loss. (A–D) Maximum-intensity projections of confocal images of WT (A,B) and mpv17^a9/a9(C,D) control neuromasts (A–C) or exposed to 10 μM neomycin (B,D). Hair cells were visualized with immunolabel of Parvalbumin (magenta), afferent neurites are expressing GFP (green), and all cell nuclei are labeled with DAPI (blue). (E) Dose-response curves showing hair cell survival as a percentage of control in both WT and mpv17^a9/a9 neuromasts (*P = 0.0115; ***P = 0.0001; ****P < 0.0001). n = 67–86 neuromasts (L3, L4, and L5); N = 3 experimental trials. Scale bar: 5 μm. Error bars: SD.

Acknowledgments

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