FIGURE

Fig 7

ID

ZDB-FIG-210725-79

Publication

Qiu et al., 2021 - Multiple morphogens and rapid elongation promote segmental patterning during development

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Fig 7

Boundary sharpness and rhombomere lengths based on simulations with random parameters in gene regulation.

Parameters for gene regulation were randomly perturbed and a total of n = 1000 simulations are displayed for each convergence rate. There are 513, 563 and 452 simulations for rapid, medium and slow initial convergence, respectively, which successfully generate the r2-6 pattern with four boundaries. (A-F) Dot plots showing the relationship between rhombomere length and boundary sharpness. Each point represents the corresponding quantities for each simulation. (A-C) Length of r4 versus sharpness index (SI) of the r4/r5 boundary with: (A) rapid initial convergence, (B) slow initial convergence and (C) a comparison between rapid and slow initial convergence. (D-F) Length of r5 versus SI of r5/r6 boundary with: (D) rapid initial convergence, (E) slow initial convergence and (F) a comparison between rapid and slow initial convergence. (G) Fractions of simulations achieving roughly equal rhombomere lengths versus the deviation d%. With a deviation d, a simulation has roughly equal rhombomere lengths if the length of each rhombomere is deviated at most d% from its average experimental length (i.e. r3, r4 and r5 are in the ranges of 42*(100%±d%) μm, 34*(100%±d%) μm and 37*(100%±d%) μm, respectively).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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