FIGURE

Figure 4

ID

ZDB-FIG-210628-36

Publication

Faria et al., 2021 - Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Effects over gene and enzyme activity levels in whole body of 8 dpf old zebrafish larvae following pharmacological modulation of the serotonergic system. (A) Expression of tph1α involved in serotonin synthesis process; (B,C) Expression of mao and MAO activity, respectively, involved in the degradation of serotonin; (D) Expression of sert and vmat2 genes that respectively regulate serotonin transport from the synaptic cleft back to the presynaptic neuron and the transport of serotonin form the cell cortisol into synaptic vesicles. Data are from 2 independent experiments and are reported as scatter plots with the median (red line) and n = 6–8 for all treatment groups. Significance was set to p < 0.05 and can be represented as * when p < 0.05; ** when p < 0.01 and *** when p < 0.001, one-way ANOVA with Dunnett’s multiple comparison test.

Expression Data

Genes:	slc18a2 tph1a
Fish:	WT
Conditions:	chemical treatment by environment: 4-chloro-L-phenylalanine chemical treatment by environment: selegiline hydrochloride chemical treatment by environment: 4-chloro-L-phenylalanine
Anatomical Term:	head
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: 4-chloro-L-phenylalanine chemical treatment by environment: selegiline hydrochloride chemical treatment by environment: 4-chloro-L-phenylalanine
Observed In:	head serotonin catabolic process
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Toxics