FIGURE

Fig. 4

ID

ZDB-FIG-210613-9

Publication

Fustin et al., 2020 - Methylation deficiency disrupts biological rhythms from bacteria to humans

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Fig. 4

Cyanobacteria are less sensitive to AHCY inhibition.

a Mean luminescence ± SEM of Synechococcus PCC 7942 kaiBCp::luxAB knock-in strain treated with different concentrations of DZnep, n = 3 colonies, with only the upper section of the error bars and higher DZnep concentrations shown on a different graph for clarity; b shows mean period ± SEM, n = 3 colonies. c Mean luminescence ± SEM of Synechococcus PCC 7942 kaiBCp::luxAB treated with different Sinefungin concentrations as indicated over the graphs; d shows mean period ± SEM, n = 3 colonies. e Organization of the methyl cycle, with the two-steps SAH conversion to homocysteine in bacteria, starting with MTAN. One arrow represents one enzyme, except for methyltransferases that all use SAM as a co-substrate to methylate different targets, generating SAH in the process. The enzyme AHCY, mediating SAH hydrolysis and inhibited by DZnep, is indicated on the picture. All bar graphs analyzed by One-Way ANOVA followed by Bonferroni’s test; all indicated comparisons (a vs. b vs. c vs. d) at least p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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