PUBLICATION
Methylation deficiency disrupts biological rhythms from bacteria to humans
- Authors
- Fustin, J.M., Ye, S., Rakers, C., Kaneko, K., Fukumoto, K., Yamano, M., Versteven, M., Grünewald, E., Cargill, S.J., Tamai, T.K., Xu, Y., Jabbur, M.L., Kojima, R., Lamberti, M.L., Yoshioka-Kobayashi, K., Whitmore, D., Tammam, S., Howell, P.L., Kageyama, R., Matsuo, T., Stanewsky, R., Golombek, D.A., Johnson, C.H., Kakeya, H., van Ooijen, G., Okamura, H.
- ID
- ZDB-PUB-210612-11
- Date
- 2020
- Source
- Communications biology 3: 211 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Arabidopsis/physiology
- Caenorhabditis elegans/physiology
- Chlamydomonas reinhardtii/physiology
- Chlorophyta/physiology
- Circadian Rhythm*
- Drosophila melanogaster/physiology
- Humans
- Methylation*
- Mice/physiology
- Synechococcus/physiology
- Zebrafish/physiology
- PubMed
- 32376902 Full text @ Commun Biol
Citation
Fustin, J.M., Ye, S., Rakers, C., Kaneko, K., Fukumoto, K., Yamano, M., Versteven, M., Grünewald, E., Cargill, S.J., Tamai, T.K., Xu, Y., Jabbur, M.L., Kojima, R., Lamberti, M.L., Yoshioka-Kobayashi, K., Whitmore, D., Tammam, S., Howell, P.L., Kageyama, R., Matsuo, T., Stanewsky, R., Golombek, D.A., Johnson, C.H., Kakeya, H., van Ooijen, G., Okamura, H. (2020) Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications biology. 3:211.
Abstract
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.
Errata / Notes
This article is corrected by ZDB-PUB-220906-206.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping