FIGURE

Fig. 2

ID

ZDB-FIG-210613-7

Publication

Fustin et al., 2020 - Methylation deficiency disrupts biological rhythms from bacteria to humans

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Fig. 2

Circadian rhythms are a quantitative gauge for methylation deficiency in Metazoa.

a Mean luminescence ± SEM of human Bmal1-luc U-2 OS cells²⁵ treated with increasing concentrations of DZnep; b shows mean ± SEM of period, n = 3 dishes. c Mean luminescence ± SEM of PER2::LUC MEF²⁴ treated with DZnep, n = 3 dishes; mean ± SEM of period shown in d. e Mean luminescence ± SEM of Per1b-luciferase PAC-2 zebrafish cells treated with DZnep, n = 4 dishes; mean ± SEM of period shown in f; note the initial 96 h of data performed under light/dark cycles. g Mean luminescence ± SEM of ptim-TIM-LUC Drosophila halteres treated with DZnep, n = 8 independent halteres, with only the upper segment of the error bars shown for clarity; mean ± SEM of period shown in h. All bar graphs analyzed by One-Way ANOVA followed by Bonferroni’s test; all indicated comparisons (a vs. b vs. c vs. d vs. e), at least p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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