FIGURE

Fig. 2

ID

ZDB-FIG-210427-12

Publication

Lu et al., 2021 - Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models

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Fig. 2

Cardioprotective effects of CA against Dox-induced cardiotoxicity in adult zebrafish. (A) Schematic of the schedule for CA administration and DOX injection. (B) High frequency echocardiography was performed at 56 days post injection to quantify cardiac functions. 0.01% DMSO was used as a control. (n = 15 per group) (C) CA treated fish showed less pathological cardiac remodeling after long-term doxorubicin treatment, examined by relative mRNA levels of nppa and nppb gene. n = 3 per group. One-way ANOVA followed by the Tukey post hoc test was used to compare multiple groups for each gene. (D) HE staining showed that CA preserved cardiomyocyte architecture. *P < 0.05, **P < 0.01.

Expression Data

Genes:	nppa nppb
Fish:	WT
Conditions:	chemical treatment by injection: doxorubicin chemical treatment by environment: calycosin, chemical treatment by injection: doxorubicin
Anatomical Term:	heart
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by injection: doxorubicin chemical treatment by environment: calycosin, chemical treatment by injection: doxorubicin
Observed In:	heart heart contraction trabecular layer muscle
Stage:	Adult

Phenotype Detail

Acknowledgments

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