FIGURE

Fig. 1

ID

ZDB-FIG-210427-11

Publication

Lu et al., 2021 - Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models

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Fig. 1

Calycosin improved the survival rate and reduced DIC in zebrafish embryos. (A) Experimental scheme for inducing cardiomyopathy in embryonic zebrafish. (DOX, 100 μM doxorubicin; CA, Calycosin; dpf, days post fertilization); (B) Representative images of no treatment, DOX-treated and DOX and 10 μM CA treated heart (DMSO control), arrows indicate location of the ventricle; (C, D) Quantification of fractional shortening and heart rate. n = 8 per group, one-way ANOVA followed by post hoc Tukey’s test was used. (E) CA treatment exerts salutary effects on embryonic DIC. n = 15. *P < 0.05, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: doxorubicin chemical treatment by environment: doxorubicin
Observed In:	atrium cardiac ventricle pericardium whole organism
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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