FIGURE

Figure 1

ID

ZDB-FIG-210409-211

Publication

Damera et al., 2021 - Role of Extracellular Mycobacteria in Blood-Retinal Barrier Invasion in a Zebrafish Model of Ocular TB

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Figure 1

Ocular infection and granuloma formation with wild-type Mycobacterium marinum (Mm) in mpeg1:BB transgenic larvae. (A) Frequency of ocular infection following caudal vein infection with 25 colony-forming units (CFU) of Mm, 1–6 days post-injection (dpi). Granuloma formation was seen in six (33.3%) of the 18 eye-infected larvae. The kinetics of granuloma formation in all six eyes were as follows: (B) extracellular Mm (green) seeded in the eye at 1 dpi. The Mm remained extracellular until 3 dpi. (C) Mm phagocytosed inside a solitary macrophage (red) at 4 dpi. (D) Compact granuloma formation at 6 dpi, comprising macrophages with or without phagocytosed Mm. All images in the figure are from the same larva.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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