ZFIN ID: ZDB-FIG-210311-54
Badrock et al., 2020 - Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts. American journal of human genetics   106(5):694-706 Full text @ Am. J. Hum. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage Range: Prim-5 to Long-pec
PHENOTYPE:
Fish:
Observed In:
Stage Range: Prim-5 to Long-pec

Fig. 6 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
baxa snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
tp53zdf1/zdf1; snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
ccng1 snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
cdkn1a snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
tp53zdf1/zdf1; snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
mdm2 snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
tp53zdf1/zdf1; snord118aue501/ue501 standard conditions Long-pec whole organism RTPCR
Venus snord118aue501/ue501; ue503Tg standard conditions Prim-5 eye IFL
Prim-5 hindbrain IFL
Prim-5 somite IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
snord118aue501/ue501 standard conditions Long-pec whole organism baxa expression increased amount, abnormal
Long-pec whole organism ccng1 expression increased amount, abnormal
Long-pec whole organism cdkn1a expression increased amount, abnormal
Long-pec whole organism mdm2 expression increased amount, abnormal
snord118aue501/ue501; s843Tg standard conditions Prim-5 angiogenic sprout decreased amount, abnormal
snord118aue501/ue501; ue503Tg standard conditions Prim-5 eye Venus expression increased amount, abnormal
Prim-5 hindbrain Venus expression increased amount, abnormal
Prim-5 somite Venus expression increased amount, abnormal
tp53zdf1/zdf1; snord118aue501/ue501 standard conditions Long-pec whole organism baxa expression amount, ameliorated
Long-pec whole organism cdkn1a expression amount, ameliorated
Long-pec whole organism mdm2 expression amount, ameliorated
tp53zdf1/zdf1; snord118aue501/ue501; s843Tg standard conditions Prim-5 angiogenic sprout amount, ameliorated
Full text @ Am. J. Hum. Genet.