ZFIN ID: ZDB-GENE-990415-153
Gene Name: MDM2 proto-oncogene
Gene Symbol: mdm2    Nomenclature History

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Previous Names: etID309863.4 (1), sb:eu923, zgc:109834

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and transferase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell cycle arrest; and pronephric glomerulus morphogenesis. Predicted to localize to the cytoplasm; nucleolus; and nucleoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma multiforme; ichthyosis; and sarcoma. Is expressed in several structures, including blood; intestine; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Orthologous to human MDM2 (MDM2 proto-oncogene).
Genome Resources: Alliance (1),  Gene:30637 (1),  Ensembl(GRCz11):ENSDARG00000033443 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14240 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16808 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20278 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26298 Point Mutation Unknown Splice Site ENU
    sq25 Small Deletion Exon 7 Premature Stop ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sq26 Insertion Exon 7 Premature Stop ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sq27 Insertion Exon 7 Premature Stop ZINC_FINGER_NUCLEASE
    sq28 Small Deletion Exon 7 Inframe Deletion ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mdm2 N/A 7
    MO2-mdm2 N/A 2
    MO3-mdm2 N/A 3
    TALEN1-mdm2
    1
    DISEASE ASSOCIATED WITH mdm2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Lessel-Kubisch syndrome 618681
    {Accelerated tumor formation, susceptibility to} 614401
    DISEASE ASSOCIATED WITH mdm2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR001876 Zinc finger, RanBP2-type
    Domain IPR003121 SWIB/MDM2 domain
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Family IPR015459 Ubiquitin-protein ligase E3 MDM2
    Family IPR016495 p53 negative regulator Mdm2/Mdm4
    Domain IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal
    Family IPR028340 E3 ubiquitin-protein ligase Mdm2
    Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
    Homologous_superfamily IPR036885 SWIB/MDM2 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mdm2-201 (1)    Ensembl 1965
    mdm2-206 (1)    Ensembl 584
    ncRNA mdm2-002 (1)    Ensembl 642
    mdm2-003 (1)    Ensembl 294
    mdm2-004 (1)    Ensembl 607
    mdm2-006 (1)    Ensembl 400
    Browsers: UCSCEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mdm2 polyclonal IgG Rabbit IHC AnaSpec
    4
    CONSTRUCTS WITH SEQUENCES FROM mdm2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(mdm2:GFP) mdm2 GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    mdm2 Contained in: [BAC] CH211-149P5 (1), DKEYP-86A5 (1)
    mdm2 Encodes: [EST] eu923 (1), fc16b11
    [cDNA] MGC:109834 (1), MGC:113866 (1), MGC:192439 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131364 (1) 1788 bp
    Genomic GenBank:AL929141 (1) 182116 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ISQ1 (1) 486 aa
    Sequence Information (all 39)
    ORTHOLOGY for mdm2 ( Chr: 4 )
    CITATIONS (142)