ZFIN is now using GRCz12tu for Genomic Data
Gene
mdm2
- ID
- ZDB-GENE-990415-153
- Name
- MDM2 proto-oncogene
- Symbol
- mdm2 Nomenclature History
- Previous Names
-
- etID309863.4 (1)
- sb:eu923
- zgc:109834
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blood; digestive system; head; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 88 figures from 70 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109834 (11 images)
- eu923 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Domain | IPR003121 | SWIB/MDM2 domain |
| Domain | IPR044080 | MDM2, modified RING finger, HC subclass |
| Family | IPR016495 | p53 negative regulator Mdm2/Mdm4 |
| Family | IPR028340 | E3 ubiquitin-protein ligase Mdm2 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
| Homologous_superfamily | IPR036885 | SWIB/MDM2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase Mdm2 | MDM2, modified RING finger, HC subclass | p53 negative regulator Mdm2/Mdm4 | SWIB/MDM2 domain | SWIB/MDM2 domain superfamily | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:O42354 | InterPro PDB | 445 | |||||||||
| UniProtKB:A0A8M2BC69 | InterPro | 486 | |||||||||
| UniProtKB:Q561Z0 | InterPro | 475 | |||||||||
| UniProtKB:A0A8N1Z1T6 | InterPro | 475 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mdm2-201
(1)
|
Ensembl | 1,965 nt | ||
| mRNA |
mdm2-202
(1)
|
Ensembl | 2,812 nt | ||
| mRNA |
mdm2-206
(1)
|
Ensembl | 584 nt | ||
| mRNA |
mdm2-208
(1)
|
Ensembl | 3,486 nt | ||
| mRNA |
mdm2-209
(1)
|
Ensembl | 911 nt | ||
| ncRNA |
mdm2-002
(1)
|
Ensembl | 642 nt | ||
| ncRNA |
mdm2-003
(1)
|
Ensembl | 294 nt | ||
| ncRNA |
mdm2-004
(1)
|
Ensembl | 607 nt | ||
| ncRNA |
mdm2-006
(1)
|
Ensembl | 400 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers