Gene

mdm2

ID
ZDB-GENE-990415-153
Name
MDM2 proto-oncogene
Symbol
mdm2 Nomenclature History
Previous Names
  • etID309863.4 (1)
  • sb:eu923
  • zgc:109834
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Is predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell cycle arrest; and pronephric glomerulus morphogenesis. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including blood; digestive system; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
55 figures from 40 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdm2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Lessel-Kubisch syndrome 618681
{Accelerated tumor formation, susceptibility to} 614401
Associated With mdm2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR001876 Zinc finger, RanBP2-type
Domain IPR003121 SWIB/MDM2 domain
Domain IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal
Domain IPR044080 MDM2, modified RING finger, HC subclass
Family IPR015459 Ubiquitin-protein ligase E3 MDM2
Family IPR016495 p53 negative regulator Mdm2/Mdm4
Family IPR028340 E3 ubiquitin-protein ligase Mdm2
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
Homologous_superfamily IPR036885 SWIB/MDM2 domain superfamily
Domain Details Per Protein
Protein Length E3 ubiquitin-protein ligase Mdm2 MDM2, modified RING finger, HC subclass p53 negative regulator Mdm2/Mdm4 SWIB/MDM2 domain SWIB/MDM2 domain superfamily U1 small nuclear ribonucleoprotein of 70kDa N-terminal Ubiquitin-protein ligase E3 MDM2 Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:F1QU48 440
UniProtKB:A0A2R8RRT2 470
UniProtKB:O42354 445
UniProtKB:Q4V9B1 164
UniProtKB:B0R0S8 475
UniProtKB:A0A2R8Q0X4 95
UniProtKB:Q561Z0 475
UniProtKB:A0A0R4ISQ1 486
UniProtKB:A0A2R8Q7A7 147
UniProtKB:B0R0S9 159
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mdm2 polyclonal IgG Rabbit
  • IHC
AnaSpec
4
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations