FIGURE

Figure 3—figure supplement 3.

ID

ZDB-FIG-210224-31

Publication

Xu et al., 2021 - Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

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Figure 3—figure supplement 3.

Accessibility of cartilage-enriched elements in earlier pan- and dorsal CNCCs.

(A,B) Heatmaps of the 5,736 distal elements with accessibility in 72 hpf chondrocytes. Their accessibility is then plotted according to μATACseq data from fli1a:GFP+; sox10:Dsred+ (pan-CNCCs) and pou3f3b>GFP+; sox10:Dsred+ (dorsal CNCCs) at 36 hpf (A) and 48 hpf (B). At 36 hpf, 132 peaks were more accessible in pan-CNCCs and 106 peaks more accessible in dorsal CNCCs. At 48 hpf, 2,470 peaks were more accessible in pan-CNCCs and 10 peaks more accessible in dorsal CNCCs. Peaks commonly or not accessible in both data sets are also shown. (C,D) Pearson correlation graphs of the behavior of cartilage-associated distal elements in pan- versus dorsal CNCCs at 36 and 48 hpf. x and y axes represent raw read counts from BAM files, and ‘r’ is the Pearson correlation coefficient.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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