FIGURE

Fig. 8

ID

ZDB-FIG-210216-57

Publication

Fallah et al., 2020 - Effects of gonadotropin-inhibitory hormone on early and late stages of spermatogenesis in ex-vivo culture of zebrafish testis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Fig. 8. A proposed model of the paracrine effects of zGnih and gonadotropins (Lh and Fsh) on zebrafish spermatogenesis. The figure illustrates the progression of spermatogenesis from type A undifferentiated spermatogonia to haploid spermatozoa cells in the presence of locally produced zGnih peptides from germ cells, Sertoli cells, and Leydig cells (Fallah et al., 2019). The diagram also illustrates the involvement of Leydig cells in the production of androgens leading to cellular differentiation, meiosis and spermiogenesis. Lh and Fsh signaling both stimulate spermatogenesis; however, they differentially regulate this process and function on different phases of spermatogenesis. zGnih is capable of inhibiting both Lh and Fsh induced-spermatogenesis by altering the number of spermatogonia cells and their proliferative activity or affecting the androgen production. Blocked lines represent inhibition. A_und: type A undifferentiated spermatogonia, A_diff: type A differentiated spermatogonia, B: type B spermatogonia, SPC: spermatocytes, SPD: spermatids, SPZ: spermatozoa.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Molecular and Cellular Endocrinology, 520, Fallah, H.P., Rodrigues, M.S., Zanardini, M., Nóbrega, R.H., Habibi, H.R., Effects of gonadotropin-inhibitory hormone on early and late stages of spermatogenesis in ex-vivo culture of zebrafish testis, 111087, Copyright (2020) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.