FIGURE

Figure 8

ID

ZDB-FIG-210128-121

Publication

Fish et al., 2021 - Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders

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Figure 8

Fluorescent thrombocyte binding and aggregation after PCV laser injury in fga^?/? larvae with transgenic A?E or A?E R28C expression: a model of dysfibrinogenemia. (A) A scheme representing the experimental setup. Early Tg(itga2b:EGFP), fga^?/? embryos were microinjected with Tol2 transgenesis plasmids for expression of fibrinogen A?E or A?E R28C, A?E + A?E R28C or a half quantity of A?E (A?E ½). Tol2 transposase mRNA was also present in injection mixes (not shown). (B) Fluorescent thrombocyte binding and adhesion at 5 dpf were monitored for each experimental group over time after PCV laser injury. Each line represents the mean fluorescence (+/?SEM). The number of larvae per group is shown in brackets.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fga^ug701/ug701
Condition:	light damage: posterior caudal vein
Observed In:	posterior caudal vein blood coagulation, fibrin clot formation posterior caudal vein platelet aggregation
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.