FIGURE

Figure 1

ID

ZDB-FIG-210128-114

Publication

Fish et al., 2021 - Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders

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Figure 1

Laser-induced venous thrombosis in an afibrinogenemia model. (A) Diagram of time-to-occlusion (TTO) assay. The posterior caudal vein (PCV) is targeted for laser injury (region represented by the red circle) near the 5th somite distal to the cloaca and the time to PCV occlusion measured. A 3-min cut-off is used to determine no occlusion. (B) TTO in seconds (s) in 3 dpf fga^+/+, fga^+/? and fga^?/? larvae. Each circle represents an individual larva. (C) Time lapse images of 3 dpf fga^+/+ and fga^?/? larvae before and after laser injury at the position marked (LI). DA is the dorsal aorta.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fga^ug701/ug701 fga^ug701/+
Condition:	light damage: posterior caudal vein
Observed In:	posterior caudal vein blood coagulation, fibrin clot formation posterior caudal vein platelet aggregation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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