FIGURE

Figure 2

ID

ZDB-FIG-210128-115

Publication

Fish et al., 2021 - Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders

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Figure 2

Thrombocyte adhesion and aggregation in afibrinogenemic zebrafish. (A) Laser-induced vessel injury to measure thrombocyte binding and accumulation in 5 dpf Tg(itga2b:EGFP) embryos with fluorescent thrombocytes. The thrombocyte-associated green fluorescence accumulation after laser injury within a defined region was measured over time for individual larvae. Each line represents the mean fluorescence (+/− SEM) for each group. The number of larvae per group is indicated in brackets. (B) Images from fga^+/+ and fga^−/− larvae upon (0 s) and after laser injury, times as indicated. The dorsal aorta (DA), posterior cardinal vein (PCV) and site of laser injury (LI, arrow) are indicated. Green near the laser injury site (arrow head) indicates the laser flash (0 s) and the accumulation of green fluorescent thrombocytes at later time points.

Expression Data

Gene:	EGFP
Fish:	la2Tg fga^ug701/+; la2Tg fga^ug701/ug701; la2Tg
Condition:	light damage: posterior caudal vein
Anatomical Term:	thrombocyte
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fga^ug701/+; la2Tg fga^ug701/ug701; la2Tg
Condition:	light damage: posterior caudal vein
Observed In:	posterior caudal vein blood coagulation, fibrin clot formation posterior caudal vein platelet aggregation
Stage:	Day 5

Phenotype Detail

Acknowledgments

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