FIGURE

Figure 3.

ID

ZDB-FIG-200904-20

Publication

Hu et al., 2020 - Loss of the RNA-binding protein Rbm15 disrupts liver maturation in zebrafish

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Figure 3.

Hepatoblast specification is normal in the cq96 mutant.A, WISH results of gata6, prox1, foxa3, and hhex at 60 hpf revealing hepatic formation and specification in cq96 and WT. B, confocal images showing the antibody staining of Hnf4a and Dendra2 at 5 dpf in cq96 mutant. C, the quantification of Hnf4a fluorescent intensity in WT and cq96. D, confocal images showing the antibody staining of Prox1 and 2F11 in WT and mutant at 5 dpf. E, the quantification of Prox1 fluorescent intensity in WT and cq96. Numbers indicate the proportion of larvae exhibiting the expression shown. Asterisks indicate statistical significance: ***, p < 0.001; ****, p < 0.0001. Scale bars, 100 μm; error bars, S.D.

Expression Data

Genes:	foxa3 gata6 hhex hnf4a
Antibody:	ab1-hnf4a
Fish:	WT rbm15^cq96/cq96 cq1Tg rbm15^cq96/cq96; cq1Tg
Anatomical Terms:	hepatocyte liver
Stage Range:	Pec-fin to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rbm15^cq96/cq96; cq1Tg
Observed In:	hepatocyte
Stage:	Day 5

Phenotype Detail

Acknowledgments

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