Gene

hnf4a

ID

ZDB-GENE-030131-1077

Name

hepatocyte nuclear factor 4, alpha

Symbol

hnf4a Nomenclature History

Previous Names

fb58h09
id:ibd1279
NR2A1 (1)
sb:eu665
wu:fb58h09

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity. Involved in pancreas regeneration; response to bacterium; and type B pancreatic cell development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Is expressed in gut; intestinal bulb primordium; liver; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

54 figures from 27 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu665 (4 images)
af473824 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hnf4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fanconi renotubular syndrome 4	Alliance	Fanconi renotubular syndrome 4, with maturity-onset diabetes of the young	616026
maturity-onset diabetes of the young type 1	Alliance	MODY, type I	125850
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, noninsulin-dependent}	125853

Associated With hnf4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Family	IPR001723	Nuclear hormone receptor
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily

Domain Details Per Protein

Protein	Length	Nuclear hormone receptor	Nuclear hormone receptor, ligand-binding domain	Nuclear hormone receptor-like domain superfamily	Zinc finger, NHR/GATA-type	Zinc finger, nuclear hormone receptor-type
UniProtKB:A0A8M9PKL5 InterPro	446
UniProtKB:A0A8M9P510 InterPro	435
UniProtKB:A0A8M9PEX6 InterPro	470
UniProtKB:A0A8M9PSX4 InterPro	440
UniProtKB:Q8AXB6 InterPro	454
UniProtKB:A8E5K2 InterPro	427

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hnf4a-202 (1) Ensembl	Havana	1732 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hnf4a-204 (1) Ensembl	Havana	850 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hnf4a-206 (1) Ensembl	Havana	3523 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hnf4a-003 (1) Ensembl	Havana	339 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hnf4a-004 (1) Ensembl	Havana	732 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
ab1-hnf4a	polyclonal	hnf4a	IgG	Goat	IHC	Santa Cruz Biotechnology, Inc.	14

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations