Gene

hnf4a

ID

ZDB-GENE-030131-1077

Name

hepatocyte nuclear factor 4, alpha

Symbol

hnf4a Nomenclature History

Previous Names

fb58h09
id:ibd1279
NR2A1 (1)
sb:eu665
wu:fb58h09

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity. Involved in pancreas regeneration; response to bacterium; and type B pancreatic cell development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Is expressed in gut; intestinal bulb primordium; liver; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

54 figures from 27 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu665 (4 images)
af473824 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hnf4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fanconi renotubular syndrome 4	Alliance	Fanconi renotubular syndrome 4, with maturity-onset diabetes of the young	616026
maturity-onset diabetes of the young type 1	Alliance	MODY, type I	125850
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, noninsulin-dependent}	125853

Associated With hnf4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Domain	IPR049635	Hepatocyte nuclear factor 4, ligand-binding domain
Domain	IPR049636	Hepatocyte nuclear factor 4-like, DNA-binding domain
Family	IPR001723	Nuclear hormone receptor
Family	IPR050274	Nuclear hormone receptor family NR2 subfamily
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily

Domain Details Per Protein

Protein	Length	Hepatocyte nuclear factor 4, ligand-binding domain	Hepatocyte nuclear factor 4-like, DNA-binding domain	Nuclear hormone receptor	Nuclear hormone receptor family NR2 subfamily	Nuclear hormone receptor, ligand-binding domain	Nuclear hormone receptor-like domain superfamily	Zinc finger, NHR/GATA-type	Zinc finger, nuclear hormone receptor-type
UniProtKB:A0A8M9PKL5 InterPro	446
UniProtKB:A0A8M9P510 InterPro	435
UniProtKB:A0A8M9PEX6 InterPro	470
UniProtKB:A0A8M9PSX4 InterPro	440
UniProtKB:Q8AXB6 InterPro	454
UniProtKB:A8E5K2 InterPro	427

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hnf4a-202 (1) Ensembl	Ensembl	1,732 nt	Select Tool ZFIN BLAST
mRNA	hnf4a-201 (1) Ensembl	Ensembl	3,268 nt	Select Tool ZFIN BLAST
mRNA	hnf4a-204 (1) Ensembl	Ensembl	850 nt	Select Tool ZFIN BLAST
mRNA	hnf4a-206 (1) Ensembl	Ensembl	3,523 nt	Select Tool ZFIN BLAST
ncRNA	hnf4a-003 (1) Ensembl	Ensembl	339 nt	Select Tool ZFIN BLAST
ncRNA	hnf4a-004 (1) Ensembl	Ensembl	732 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
ab1-hnf4a	polyclonal	hnf4a	IgG	Goat	IHC	Santa Cruz Biotechnology, Inc.	15

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations