FIGURE

Figure 2

ID

ZDB-FIG-200829-9

Publication

Hudson et al., 2020 - Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

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Figure 2

Berbamine analogs confer protection from neomycin. Analog BA-4 is shown here as an example. (A) Zebrafish labeled with the mitochondrial dye DASPEI to visualize neuromasts in the lateral line (white dots). Scale bar = 1 mm. (B) Zebrafish labeled with DASPEI after 200 μM neomycin resulting in reduced fluorescence. (C) Zebrafish labeled with DASPEI after pre-co treatment with analog BA-4 and 200 μM neomycin. (D,E) Representative IO3 neuromasts from Tg(Brn3c:GFP) zebrafish. (D) Zebrafish exposed to 200 μM neomycin exposure, resulting in hair cell loss. Scale bar = 10 μm. (E) Zebrafish exposed to a pre-co treatment of analog BA-4 and 200 μM neomycin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.