ZFIN Image: Hudson et al., 2020, Figure 2

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Figure Caption

Figure 2

Berbamine analogs confer protection from neomycin. Analog BA-4 is shown here as an example. (A) Zebrafish labeled with the mitochondrial dye DASPEI to visualize neuromasts in the lateral line (white dots). Scale bar = 1 mm. (B) Zebrafish labeled with DASPEI after 200 μM neomycin resulting in reduced fluorescence. (C) Zebrafish labeled with DASPEI after pre-co treatment with analog BA-4 and 200 μM neomycin. (D,E) Representative IO3 neuromasts from Tg(Brn3c:GFP) zebrafish. (D) Zebrafish exposed to 200 μM neomycin exposure, resulting in hair cell loss. Scale bar = 10 μm. (E) Zebrafish exposed to a pre-co treatment of analog BA-4 and 200 μM neomycin.

Acknowledgments

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