FIGURE

Fig. 1

ID

ZDB-FIG-200801-2

Publication

Cang et al., 2020 - Inferring spatial and signaling relationships between cells from single cell transcriptomic data

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Fig. 1

Overview of SpaOTsc.

a The unbalanced transport relaxes the mass conservation constraint (e.g. lines between circles), and the structured transport utilizes additional information (e.g. dotted links) to refine the mapping (e.g. blue hexagon). b Cell–cell distance is inferred by computing optimal transport distance of the spatial probability distributions of cells (rows of γ in a). c Calculated cell–cell distance, along with partial information decomposition and random forest models, is used to infer spatial distance of signaling and then construct space-constrained cell–cell communications and identify potential intercellular regulation between genes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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