IMAGE

Fig. 1

ID: ZDB-IMAGE-200801-5
Publication: Cang et al., 2020 - Inferring spatial and signaling relationships between cells from single cell transcriptomic data
All Figures: Figures for Cang et al., 2020

Image

Figure Caption

Fig. 1 Overview of SpaOTsc.

a The unbalanced transport relaxes the mass conservation constraint (e.g. lines between circles), and the structured transport utilizes additional information (e.g. dotted links) to refine the mapping (e.g. blue hexagon). b Cell–cell distance is inferred by computing optimal transport distance of the spatial probability distributions of cells (rows of γ in a). c Calculated cell–cell distance, along with partial information decomposition and random forest models, is used to infer spatial distance of signaling and then construct space-constrained cell–cell communications and identify potential intercellular regulation between genes.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.