FIGURE

Figure 4

ID
ZDB-FIG-200426-9
Publication
Bertolini et al., 2019 - Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance
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Figure 4

Distal Anchors in Sox2-Dependent Interactions Drive GFP Transgene Activity to Zebrafish Brain

Top: enhancer-dependent GFP-reporter (ZED): distal anchors (DA) from Sox2-dependent interactions are cloned upstream to a minimal promoter and GFP. Bottom: first and second left columns, GFP expression in transgenic embryos and bright-field images (F1 of stable lines, except for c-fos, transient transgenics). Third column: expression (in situ hybridization from http://zfin.org) of the endogenous zebrafish gene corresponding to the gene connected, in mouse, to the tested anchor. Fourth column: forebrain lacZ staining driven by transgenes carrying the human enhancers corresponding to the anchor (from https://enhancer.lbl.gov) (Visel et al., 2009).

See also Figure S6 and Table S6.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Stem Cell
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