FIGURE

Figure 3

ID

ZDB-FIG-200426-8

Publication

Bertolini et al., 2019 - Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance

Other Figures

All Figure Page

Back to All Figure Page

Figure 3

Distal Anchors Connected by Sox2-Dependent Interactions to Genes Important in Neural Development and Disease

(A and B) Sox2-dependent ChIA-PET interactions (TR1) between two different genes (Sox4, A; Zbtb18, B) and distal regions overlapping previously characterized “VISTA” enhancers (Visel et al., 2009); SOX2 ChIP-seq peaks (present paper), lacZ-stained transgenic embryos (from https://enhancer.lbl.gov), and evolutionary conservation (ECR browser).

(C and D) Sox2-dependent interactions (wTR1, wTR2, wTR3, mTR1, mTR2, and mTR3) involving Gpr56 (C) and Arid1a (D), two genes whose human homologs are involved in neurodevelopmental brain disease.

See also Figure S5 and Tables S5 and S6.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Stem Cell