FIGURE

Fig. 1

ID

ZDB-FIG-200416-4

Publication

Holowiecki et al., 2020 - Pbx4 limits heart size and fosters arch artery formation through partitioning second heart field progenitors and restricting proliferation

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Fig. 1

lzr mutants have an increase in ventricular CMs. (A,B) Hearts of WT and lzr embryos at 48?hpf. IHC for Sarcomeric myosin heavy chain (Mhc, red) and Atrial myosin heavy chain (Amhc, green). Images are frontal views. Arrowheads indicate the arterial pole of the heart. White arrow indicates a protrusion from the elongated OFT in a heart from a lzr embryo. Scale bar: 50?µm. (C,D) ISH for natriuretic peptide A (nppa). Images are frontal views. Arrows indicate ventricular protrusions. At least 30 embryos were examined for each condition. Scale bar: 100?µm. a, atrium; v, ventricle. (E) Number of CMs in WT (n=18) and lzr mutant (n=18) hearts with the myl7:DsRed2-NLS transgene. Atr, atrium; Vent, ventricle. Error bars indicate s.e.m. *P<0.05.

Expression Data

Gene:	nppa
Fish:	WT pbx4^b557/b557
Anatomical Terms:	atrium cardiac ventricle
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pbx4^b557/b557
Observed In:	atrium atrium cardiac muscle cell cardiac ventricle cardiac ventricle cardiac muscle cell
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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