FIGURE

Figure 7—figure supplement 1.

ID

ZDB-FIG-200215-37

Publication

Li et al., 2020 - Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

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Figure 7—figure supplement 1.

c<italic>elsr1a</italic> affects intestine growth and homeostasis.

(A) Schematic of adult zebrafish intestine showing plane of section demarcating anterior (a), middle (m), and posterior (p) domains of the intestine for analysis (after Wallace et al., 2005). (B) Histomorphology of 6 month-old wild-type sibling (wt) adult intestine showing decreasing circumference along the length of the intestine and prominent rugae growing up into the intestinal lumen. (C) Intestine of age and size matched frnt mutants. Sections stained with periodic acid-Schiff stain (PAS). (D) Quantitation of intestine area in different gut regions in wt sibling (n = 5) and frnt mutants (n = 6); data represented as mean ± standard deviation, **p<0.01; E–H). PAS and Alcian blue staining of rugae from posterior intestine from wild-type (E–F) and frnt mutant fish. Inset (E, G) showing area of F, H. Scale bars represent 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	celsr1a^{t31786/t31786} (TU)
Observed In:	intestinal bulb mid intestine
Stage:	Adult

Phenotype Detail

Acknowledgments

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