FIGURE

Figure 6

ID

ZDB-FIG-200215-35

Publication

Li et al., 2020 - Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

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Figure 6

Loss of <italic>celsr1a</italic> leads to altered polarity phenotypes in the zebrafish integument.

(A–B) Alizarin red stained adult wild-type zebrafish showing pattern of scales on the flank. (A). Wild-type fish showing normal, regularly spaced pattern of scales whereas, in (B) frnt mutants show altered patterning of scales across the flank, creating swirls. (C) Wild-type scale showing internal polarity of growth along the rostrocaudal axis (bottom to top). (D) frnt scale showing radial pattern of growth rings (annuli), without the internal polarity normally observed in wild-type. (E) Quantification of polarity in wild-type sibling and frnt scales (n = 6 fish,>25 scales each side) as indicated by the ratio of the center-to-base normalized by the diameter for each scale (C, D). Data presented as mean ± standard deviation; ****p<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	celsr1a^{t31786/t31786} (TU)
Observed In:	scale
Stage:	Adult

Phenotype Detail

Acknowledgments

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