FIGURE

Fig. 4

ID

ZDB-FIG-200203-4

Publication

Wei et al., 2020 - Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo

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Fig. 4

Src is a target of PRL-3.

a GSEA analysis of T-ALL patients samples (GSE13159) comparing bone marrow with high PRL-3 expression (upper quartile) vs low PRL-3 expression (bottom quartile), showing the normalized enrichement score (NES). Reverse-phase protein array analysis (RPPA) of (b) PRL-3 knock-down or (c) overexpression of PRL-3 in Jurkat cells showed differential protein expression when compared to controls. Red bars show any protein that was up or down regulated 20%, and protein names shown in red are common in both groups, and include Chk2, Histone H3, and Src_pY527.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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