FIGURE

Fig. 3

ID

ZDB-FIG-200203-3

Publication

Wei et al., 2020 - Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

PRL-3 enhances circulation of leukemia cells in a zebrafish T-ALL model.

a Representative images of transient transgenic zebrafish expressing rag2:Myc + rag2:mCherry (n = 11) or rag2:Myc + rag2:mCherry + rag2:prl-3 (n = 6) at 34 days post-fertilization (dpf). b Kaplan–Meier analysis of time (days) percent survival (>70% of animal is mCherry-positive). c Representative rag2:Myc + rag2:mCherry + rag2:prl-3 animal, showing circulating mCherry + leukemia cells within the tail fin. d Kaplan–Meier analysis of time (days) for each T-ALL to be visualized in circulation, * p = 0.049. e Representative images of May-Gunwald Giemsa staining of blood samples from fish from each leukemia type. Scale bar = 100 μm. f Realtime RT-PCR analysis of Myc expression between rag2:Myc + rag2:mCherry (n = 8) and rag2:Myc + rag2:mCherry + rag2:prl-3 (n = 5). Each point represents one fish sample. NS = not significant. g Realtime RT-PCR analysis of lymphocyte, T-cell, and B-cell specific genes. Bars are the average expression of three samples per group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oncogenesis