FIGURE

Fig. 5

ID

ZDB-FIG-200201-14

Publication

Iribarne et al., 2019 - TNFα Induces Müller Glia to Transition From Non-proliferative Gliosis to a Regenerative Response in Mutant Zebrafish Presenting Chronic Photoreceptor Degeneration

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Fig. 5

Müller glia express Sox2 during the regeneration response in gosh mutants. Wild-type and gosh mutant retinas at 5 wpf labeled with anti-Sox2 and anti-PCNA antibodies, and DAPI. Tg(gnat2:GFP) transgene visualizes cones. Wild-type retinas display Sox2 expression in the CMZ and amacrine cells (A,C, dotted boxes show the area magnifies in B,D). Müller glia exhibit faint expression of Sox2. At 5 wpf, gosh mutant retinas show that Sox2 expression is colocalized with PCNA in the INL (D, arrowheads) probably in Müller glia, whereas subsequently differentiating NPCs express only PCNA (D, arrows).

Expression Data

Antibody:	Ab4-sox2
Fish:	oki061Tg aipl2^s341/s341; oki061Tg
Anatomical Terms:	amacrine cell ciliary marginal zone Muller cell
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aipl2^s341/s341; oki061Tg
Observed In:	Muller cell
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

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