FIGURE

Fig. 7

ID

ZDB-FIG-200115-16

Publication

Nepal et al., 2020 - Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing

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Fig. 7

Dual-initiation (DI) promoters are conserved in human and <italic>Drosophila</italic>.

a A UCSC browser screenshot of human GAS5 promoter CAGE data (summed CTSSs) in FANTOM5 cell types. CTSSs show transcription of YR-initiation and YC-initiation within same core promoter region. b Expression levels of YR-initiations and YC-initiations by summing their CTSSs. Promoter are classified as YR-dominant or YC-dominant across individual cell types and their expression is shown in stacked bars. Y-axis shows the expression levels measured in tags per million (TPM). c Venn diagram with intersection of gene promoters with YR and YC-initiation in human HepG2 and Drosophila S2 cells. DI promoters are indicated in the overlap between detected YR-initiation and YC-initiation. d Enrichment of gene ontology terms of DI promoters in human HepG2 cell line. e Comparison of C+T sequence content around transcription start sites in DI promoters with YR-only or YC-only initiation promoter in human and drosophila. f Expression levels of DI promoter genes in human and Drosophila. g Frequency of CTSSs and promoter width of DI promoters in human and Drosophila. h UCSC browser screenshots showing CTSSs in the promoter region of RPL38 gene in human, Drosophila and zebrafish. YR-initiation and YC-initiation peaks are colored as blue and red. Boxplots show the 5th, 25th, 50th, 75th, and 95th percentiles where center line is the median.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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