FIGURE

Fig 3

ID

ZDB-FIG-191230-765

Publication

Wang et al., 2019 - microRNA-1 Regulates NCC Migration and Differentiation by Targeting sec63

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Fig 3

miR-1 morphants displayed defective migration of neural crest cells. Live embryo imaging in miR-1 morphants and negative control Tg (sox10: EGFP) embryos was used to analyze the movement of neural crest cells, viewed dorsally. (A-D) Representative images are shown from the time-lapse photography from 6 segment stage (ss) to 20 ss. At 6ss, 10 ss, 16 ss and 20 ss, neural crest cells in miR-1 morphants displayed ectopic EGFP expression (red arrowheads) in the dorsal midline (A, B, C and D). At 24 hpf, expression of snai1b (E) and tfap2a (F) in negative control and miR-1 morphants is shown. At this time, increasing numbers of the migrating lateral line primordium (arrow) expressed tfap2a and snail1b. The expression of neural crest migration markers (snai1b, tfap2a) was reduced (arrows) (E, F). microRNA-1, miR-1; morpholino, MO; ss, segment stage.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Biol. Sci.