FIGURE

Figure 5

ID
ZDB-FIG-191230-1379
Publication
Chen et al., 2019 - Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia
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Figure 5

Anemic phenotype is partially rescued by p53 konckdown in rps9 deficient embryos. (A-C) Whole mount in situ shows that p53, p21, and mdm2 are upregulated in mutants. (D) The expression of p53 and p53 target genes including mdm2 and p21 increases as measured by qPCR. The relative fold induction is represented as fold change over sibling control. (E) p53 inhibition by MO injection knockdown the gene expression of p53 and p53-target genes. (F) The morphological defects of rps9 mutant are largely rescued by p53 inhibition. (G-H) An increase of hemoglobin level appears at 48 hpf. (G) and 3 dpf (H) after p53 knockdown.
Expression Data
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Prim-5 to Long-pec

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Long-pec

Phenotype Detail
Acknowledgments
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