ZFIN ID: ZDB-FIG-190827-26
Park et al., 2019 - Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   117:109179 Full text @ Biomed. Pharmacother.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Condition:
Anatomical Term:
Stage: Adult
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Adult

Fig. 2

Chronic ethanol treatment induced steatosis in the liver of adult zebrafish. (A) The relative mRNA expression of genes associated with lipid metabolism include lipogenic transcription factors, lipid synthesis, lipid uptake, and fatty acid transporting into the mitochondria. (B) Oil red O staining the section of liver in untreated control (left) and 0.2% ethanol treated wild type zebrafish. Scale bar = 50 μm. (C) The quantification of triglycerides in the liver of control and ethanol treated zebrafish. Error bars indicate standard deviation of the mean. * p < 0.05, ** p < 0.005.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
cebpa WT chemical treatment by environment: ethanol Adult liver RTPCR
dffa WT chemical treatment by environment: ethanol Adult liver RTPCR
dgat2 WT chemical treatment by environment: ethanol Adult liver RTPCR
fasn WT chemical treatment by environment: ethanol Adult liver RTPCR
ldlra WT chemical treatment by environment: ethanol Adult liver RTPCR
lpl WT chemical treatment by environment: ethanol Adult liver RTPCR
srebf1 WT chemical treatment by environment: ethanol Adult liver RTPCR
srebf2 WT chemical treatment by environment: ethanol Adult liver RTPCR
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: ethanol Adult liver fatty, abnormal
Adult liver srebf2 expression increased amount, abnormal
Adult liver srebf1 expression increased amount, abnormal
Adult liver dffa expression increased amount, abnormal
Adult liver dgat2 expression increased amount, abnormal
Adult liver ldlra expression increased amount, abnormal
Adult liver fasn expression increased amount, abnormal
Adult liver cebpa expression increased amount, abnormal
Adult liver lpl expression increased amount, abnormal
Adult liver triglyceride increased amount, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Biomed. Pharmacother.