Gene
dgat2
- ID
- ZDB-GENE-050913-15
- Name
- diacylglycerol O-acyltransferase 2
- Symbol
- dgat2 Nomenclature History
- Previous Names
-
- zgc:113394
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable diacylglycerol O-acyltransferase activity. Acts upstream of or within lipid homeostasis; regulation of response to endoplasmic reticulum stress; and response to (R)-carnitine. Predicted to be located in lipid droplet and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in female organism; intestine; liver; and male organism. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Hare et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011848Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13945 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007130 | Diacylglycerol acyltransferase |
1 - 1 of 1
Domain Details Per Protein
| Protein | Length | Diacylglycerol acyltransferase |
|---|---|---|
|
UniProtKB:Q4V9F0
|
361 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147G3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113394 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030196 (1) | 1600 nt | ||
| Genomic | GenBank:CR293504 (2) | 165086 nt | ||
| Polypeptide | UniProtKB:Q4V9F0 (1) | 361 aa |
- Chen, P., Zhu, Z., Geng, H., Cui, X., Han, Y., Wang, L., Zhang, Y., Lu, H., Wang, X., Zhang, Y., Sun, C. (2024) Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease. Journal of pharmaceutical analysis. 14:100910100910
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Zhao, Y., Lv, H., Yu, C., Liang, J., Yu, H., Du, Z., Zhang, R. (2024) Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration. Biochimica et biophysica acta. Molecular basis of disease. 1870(7):167442
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Xu, S.S., Li, Y., Wang, H.P., Chen, W.B., Wang, Y.Q., Song, Z.W., Liu, H., Zhong, S., Sun, Y.H. (2023) Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Zoological research. 44:63-77
- Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Frontiers in nutrition. 8:797510
- Ding, Q., Lu, C., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringo, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Frontiers in nutrition. 9:894278
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
1 - 10 of 75
Show