FIGURE

Fig. 2

ID

ZDB-FIG-190307-10

Publication

Hsieh et al., 2018 - Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system

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Fig. 2

Ppar? deficiency did not affect the formation of neural progenitors. A: GW6471 treatment or injection of pparaa ?LBD or pparab ?LBD reduced the expression of acox1, as examined by quantitative real?time polymerase chain reaction (RT?qPCR). B: Schematic of pparaa ?LBD and pparab ?LBD deletion constructs. DBD, DNA?binding domain; LBD, ligand?binding domain. C?J: GW6471 treatment (C,D), injection of pparaa ?LBD or pparab ?LBD, and coinjection of pparaa ?LBD and pparab ?LBD (E,F) did not alter the expression of neural progenitor marker sox2 and the anterior neural plate marker otx2b, as examined using whole?mount in situ hybridization (C,E,G,I) and quantified through RT?qPCR (D,F,H,J). Note that the expression of sox2 at 72 hpf was not affected by Ppar? deficiency (G?J). The data represent three independent experiments. Values are expressed as the mean?±?standard deviation. **P?

Expression Data

Genes:	acox1 otx2b sox2
Fish:	TU
Condition:	chemical treatment by environment: GW 6471
Anatomical Terms:	anterior neural plate brain eye pharyngeal arch whole organism
Stage Range:	75%-epiboly to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU
Condition:	chemical treatment by environment: GW 6471
Observed In:	whole organism
Stage:	75%-epiboly

Phenotype Detail

Acknowledgments

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