FIGURE

Fig. 6

ID

ZDB-FIG-190109-1

Publication

Swaminathan et al., 2018 - Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development

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Fig. 6

Paracrine Compensation by GABA and Modulation of Multiple Independent Pathways in depdc5 Knockout Zebrafish

(A) Swimming activity of 8-dpf larvae treated with muscimol (100 μM), baclofen (100 μM), a combination of both, or vigabatrin (5 mM) with the activity of depdc5^+/+ larvae normalized to 100% shows that treatment with vigabatrin can completely rescue hypoactivity, whereas GABA receptor agonists cannot.

(B) Vigabatrin treatment completely rescues PTZ hypersensitivity of 2-dpf depdc5^−/− embryos. N = 2, n > 30; Student’s t test, ∗p < 0.05.

(C) Overlap between gene expression datasets from depdc5, gabra1, tsc2, and scn1a mutants. See also Tables S2 and S4.

(D) A representation of the common pathways (axon guidance and GABA synapse) affected in depdc5 and gabra1 knockout brains with the common genes indicated. See also Table S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL depdc5^{udm102/udm102} (TL)
Conditions:	chemical treatment by environment: baclofen chemical treatment by environment: baclofen chemical treatment by environment: muscimol chemical treatment by environment: pentetrazol chemical treatment by environment: pentetrazol chemical treatment by environment: vigabatrin
Observed In:	swimming
Stage Range:	Long-pec to Days 7-13

Phenotype Detail

Acknowledgments

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