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Fig. 6

ID: ZDB-IMAGE-190109-1
Publication: Swaminathan et al., 2018 - Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development
All Figures: Figures for Swaminathan et al., 2018

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Fig. 6 Paracrine Compensation by GABA and Modulation of Multiple Independent Pathways in depdc5 Knockout Zebrafish

(A) Swimming activity of 8-dpf larvae treated with muscimol (100 μM), baclofen (100 μM), a combination of both, or vigabatrin (5 mM) with the activity of depdc5^+/+ larvae normalized to 100% shows that treatment with vigabatrin can completely rescue hypoactivity, whereas GABA receptor agonists cannot.

(B) Vigabatrin treatment completely rescues PTZ hypersensitivity of 2-dpf depdc5^−/− embryos. N = 2, n > 30; Student’s t test, ∗p < 0.05.

(C) Overlap between gene expression datasets from depdc5, gabra1, tsc2, and scn1a mutants. See also Tables S2 and S4.

(D) A representation of the common pathways (axon guidance and GABA synapse) affected in depdc5 and gabra1 knockout brains with the common genes indicated. See also Table S3.

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Acknowledgments

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