FIGURE

Fig. S3

ID

ZDB-FIG-180703-37

Publication

Campbell et al., 2018 - Directing Nanoparticle Biodistribution Through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

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Fig. S3

Size-dependent uptake of neutral liposomes by monocytes/macrophages. A. Whole-embryo and cellular views of liposome distribution in mpeg:GFP transgenic embryos, 2h after injection with Myocet liposomes ~100nm (with and without 10 mol% DOPE-mPEG2000), 325nm and 464nm pores. Immobile liposome aggregates were observed to colocalize with mpeg:gfp positive macrophages/monocytes within the caudal hematopoietic tissue (CHT). Fluorescence intensity was found to increase with increased liposome size, and phagocytosis could be prevented by PEGylation. B. High-resolution imaging shows intracellular localization of 400nm liposomes within macrophages/monocytes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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