IMAGE

Fig. S3

ID
ZDB-IMAGE-180703-37
Source
Figures for Campbell et al., 2018
Image
Figure Caption

Fig. S3

Size-dependent uptake of neutral liposomes by monocytes/macrophages. A. Whole-embryo and cellular views of liposome distribution in mpeg:GFP transgenic embryos, 2h after injection with Myocet liposomes ~100nm (with and without 10 mol% DOPE-mPEG2000), 325nm and 464nm pores. Immobile liposome aggregates were observed to colocalize with mpeg:gfp positive macrophages/monocytes within the caudal hematopoietic tissue (CHT). Fluorescence intensity was found to increase with increased liposome size, and phagocytosis could be prevented by PEGylation. B. High-resolution imaging shows intracellular localization of 400nm liposomes within macrophages/monocytes.

Acknowledgments
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