Gene
hspa5
- ID
- ZDB-GENE-031001-11
- Name
- heat shock protein 5
- Symbol
- hspa5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Involved in response to hypoxia and response to yeast. Localizes to extracellular region. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Is expressed in several structures, including central nervous system; head; immature eye; prechordal plate; and sensory system. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 111 figures from 65 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77606 (26 images)
- cb865 (29 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Domain | IPR042050 | Endoplasmic reticulum chaperone BIP, nucleotide-binding domain |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
Domain Details Per Protein
| Protein | Length | ATPase, nucleotide binding domain | Endoplasmic reticulum chaperone BIP, nucleotide-binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SZD3
|
650 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-hspa5 | monoclonal | IgG2a | Mouse |
|
BD Biosciences
|
3 | |
| Ab12-hspa5 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
1 | |
| Ab1-hspa5 | Rabbit |
|
Sigma-Aldrich
|
3 | |||
| Ab6-hspa5 | polyclonal | Rabbit |
|
Novus Biologicals, LLC
|
4 | ||
| Ab10-hspa5 | polyclonal | IgG | Rabbit |
|
Proteintech
|
1 |
Plasmids
No data available