FIGURE

Fig. 3

ID

ZDB-FIG-180627-36

Publication

Sedykh et al., 2017 - Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tube

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Fig. 3

Dorsal hindbrain is aberrant in rfx4 mutant embryos by 24 hpf. WISH was used to visualize gene expression patterns in rfx4^uw8013 homozygotes vs rfx4^uw8013/ + sibling embryos, which develop normally, at 24 hpf. zic2a expression is reduced in the mutant dorsal hindbrain by 18 s (A,B) and remains depleted at 24 hpf (C,D). E,F: wnt3a expression is unaffected in midbrain, but reduced in hindbrain of mutant embryos. G,H: pax7a expression is unaffected in the alar plate of the midbrain and hindbrain in mutant embryos. I,J: dbx1a expression in the diencephalon and in the midbrain/hindbrain basal plate is likewise unaffected in mutants. mb, midbrain; hb, hindbrain; open arrowheads, optic stalk expression; arrows, depleted hindbrain expression.

Expression Data

Genes:	dbx1a pax7a wnt3a zic2a
Fish:	rfx4^{uw8013/uw8013} rfx4^uw8013/+
Anatomical Terms:	basal plate midbrain region diencephalon hindbrain dorsal region midbrain spinal cord
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rfx4^{uw8013/uw8013}
Observed In:	hindbrain dorsal region spinal cord
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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