FIGURE

Fig. 2

ID

ZDB-FIG-180627-35

Publication

Sedykh et al., 2017 - Zebrafish Rfx4 controls dorsal and ventral midline formation in the neural tube

Other Figures

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Fig. 2

Aberrant curvature in rfx4 mutant and morphant embryos. Heterozygous rfx4^uw8013 embryos develop normally (A), while their homozygous siblings show pronounced downward curvature (B) by 2 dpf. C: PCR genotyping of individual progeny of rfx4^uw8013/ + parents shows that the curved phenotype is linked to rfx4^uw8013 homozygosity. D,E: Embryos injected with translation‐blocking morpholino targeting rfx4 develop with downward curvature. F: The aberrant curved morphology in rfx4 morphants is independent of apoptosis. Summarized from four experiments. e, embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rfx4^{uw8013/uw8013} WT + MO1-rfx4 WT + MO1-rfx4 + MO4-tp53
Knockdown Reagents:	MO1-rfx4 MO4-tp53
Observed In:	swim bladder trunk whole organism
Stage Range:	Long-pec to Days 7-13

Phenotype Detail

Acknowledgments

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