FIGURE

Fig. 3

ID

ZDB-FIG-180620-3

Publication

Gou et al., 2018 - sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear

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Fig. 3

Effects of high-level misexpression ofsox2orsox3during early placode development. (A–H) Dorsolateral views (anterior to the left) of expression of atoh1a (A–D) and neurog1 (E–H) at 24 hpf in control (A, E), hs:sox2/hs:sox2 (B, F) and hs:sox3/hs:sox3 (C–H) embryos. (I–N) Expression of atoh1a (I–K) and neurog1 (L–N) at 24 hpf in cross sections (lateral to the left) through the middle of the otic vesicle in hs:sox2/hs:sox2 homozygotes (I, L) and hs:sox3/hs:sox3 homozygotes (J, K, M, N). hs:sox2/hs:sox2 homozygotes were heat shocked at 12.5 hpf, 39 °C for 60 min, whereas hs:sox3/hs:sox3 homozygotes were heat shocked at 12.5 hpf, 38 °C for 30 min. Otic vesicle borders are outlined.

Expression Data

Genes:	atoh1a neurog1
Fish:	x21Tg/x21Tg (AB) AB x32Tg/x32Tg (AB)
Condition:	heat shock
Anatomical Term:	otic vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	x21Tg/x21Tg (AB) x32Tg/x32Tg (AB)
Condition:	heat shock
Observed In:	otic vesicle
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B., sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear, 73-83, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.