FIGURE

Fig. 5

ID

ZDB-FIG-170901-6

Publication

Gau et al., 2017 - An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish

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Fig. 5

Loss of runx or cbfb expression affects trk receptor expression in the TG.

A-I, Colormetric in situ hybridization for trkA (A-C), trkB1 (D-F), and trkC1 (G-I) in the runx3^w144/w144 and cbfb^w128/w128 mutants focusing on the TG at 24hpf and 3dpf. J-O, Antibody staining of Elavl (green) in conjunction with fluorescent in situ hybridization for trkB1 (J-L) and trkC1 (M-O) in the runx3^w144/w144 and cbfb^w128/w128 mutants at 3dpf. P, Quantification of marker gene expression as total number of TG neurons/ganglion and as % TG at 3dpf. Arrowhead, TG; X, vagal ganglion. Scale bar: A-I 100 μm, J-O 20μm. Embryos per condition (n = 3–5). ***p<0.001. All error bars represent S.E.M.

Expression Data

Genes:	ntrk1 ntrk2a ntrk3a
Antibody:	Ab1-elavl
Fish:	WT cbfb^w128/w128 (AB) runx3^w144/w144 (AB)
Anatomical Term:	trigeminal ganglion
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cbfb^w128/w128 (AB) runx3^w144/w144 (AB)
Observed In:	trigeminal ganglion
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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