Gene
ntrk3a
- ID
- ZDB-GENE-010126-3
- Name
- neurotrophic tyrosine kinase, receptor, type 3a
- Symbol
- ntrk3a Nomenclature History
- Previous Names
-
- trkC1 (1)
- si:ch73-236b16.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within central nervous system development and negative regulation of apoptotic process. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in kidney; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010339Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023126Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13864 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24620 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30214 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38018 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38019 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 7 of 7
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000719 | Protein kinase domain |
1 - 5 of 18 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Cellular adhesion and signaling domain-containing protein | Cysteine-rich flanking region, C-terminal | Growth factor receptor NTRK | Growth factor receptor NTRK, leucine rich repeat C-terminal | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:G9JKB3 | InterPro | 576 | ||||||||||||||||||
| UniProtKB:F1QKJ0 | InterPro | 818 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ntrk3a-201
(1)
|
Ensembl | 3,475 nt | ||
| mRNA |
ntrk3a-202
(1)
|
Ensembl | 13,332 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-309L7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-256N6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-18E5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-92C6 | ZFIN Curated Data | |
| Encodes | STS | zfish44910-890h03.q1k |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256664 (1) | 3529 nt | ||
| Genomic | RefSeq:NW_018395189 (1) | 180535 nt | ||
| Polypeptide | UniProtKB:F1QKJ0 (1) | 818 aa |
- Cacialli, P., Lucini, C. (2022) Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney. Veterinary sciences. 9(6)
- Franklin, C., Dwyer, D.S. (2020) Candidate Risk Genes for Bipolar Disorder are Highly Conserved during Evolution and Highly Interconnected. Bipolar disorders. 23(4):400-408
- Hahn, K., Manuel, P., Bouldin, C. (2020) Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish. PeerJ. 8:e10479
- Nittoli, V., Sepe, R.M., Coppola, U., D'Agostino, Y., De Felice, E., Palladino, A., Vassalli, Q.A., Locascio, A., Ristoratore, F., Spagnuolo, A., D'Aniello, S., Sordino, P. (2018) A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish. The Journal of comparative neurology. 526(6):1057-1072
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gau, P., Curtright, A., Condon, L., Raible, D.W., Dhaka, A. (2017) An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish. PLoS Genetics. 13:e1006884
- Hui, S.P., Sheng, D.Z., Sugimoto, K., Gonzalez-Rajal, A., Nakagawa, S., Hesselson, D., Kikuchi, K. (2017) Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Developmental Cell. 43:659-672.e5
- Auer, T.O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J.P., Wyart, C., Suster, M., Kawakami, K., Wittbrodt, J., Baier, H., Del Bene, F. (2015) Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLIFE. 4
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
1 - 10 of 27
Show