Gene

ntrk2a

ID
ZDB-GENE-010126-1
Name
neurotrophic tyrosine kinase, receptor, type 2a
Symbol
ntrk2a Nomenclature History
Previous Names
  • trkB1 (1)
  • si:ch211-148p15.2
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of neuron projection development; and regulation of intracellular signal transduction. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Is expressed in endoderm; mesoderm; nervous system; neural tube; and pharyngeal epithelium. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ntrk2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 58 Alliance Developmental and epileptic encephalopathy 58 617830
Obesity, hyperphagia, and developmental delay 613886
Associated With ntrk2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations