Gene
ntrk2a
- ID
- ZDB-GENE-010126-1
- Name
- neurotrophic tyrosine kinase, receptor, type 2a
- Symbol
- ntrk2a Nomenclature History
- Previous Names
-
- trkB1 (1)
- si:ch211-148p15.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor receptor activity. Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; positive regulation of neuron projection development; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within cell differentiation; nervous system development; and protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in endoderm; mesoderm; nervous system; neural tube; and pharyngeal epithelium. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016423Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016424Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa544 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12452 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13707 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15536 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27277 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30907 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34500 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38713 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 58 | Alliance | Developmental and epileptic encephalopathy 58 | 617830 |
| Obesity, hyperphagia, and developmental delay | 613886 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cell Adhesion and Cytoskeletal Organization | Growth factor receptor NTRK | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B589 | InterPro | 787 | |||||||||||||||||
| UniProtKB:A0A8M3AVL1 | InterPro | 791 | |||||||||||||||||
| UniProtKB:A0A8M3B2B0 | InterPro | 447 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ntrk2a-201
(1)
|
Ensembl | 2,343 nt | ||
| mRNA |
ntrk2a-202
(1)
|
Ensembl | 3,735 nt | ||
| ncRNA |
ntrk2a-002
(1)
|
Ensembl | 550 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-236B16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-148P15 | ZFIN Curated Data | |
| Encodes | STS | zfish44906-4497e03.q1k |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001366554 (1) | |||
| Genomic | GenBank:CU468685 (1) | 108280 nt | ||
| Polypeptide | UniProtKB:A0A8M3AVL1 (1) | 791 aa |
- Maffioli, E., Angiulli, E., Nonnis, S., Grassi Scalvini, F., Negri, A., Tedeschi, G., Arisi, I., Frabetti, F., D'Aniello, S., Alleva, E., Cioni, C., Toni, M. (2022) Brain Proteome and Behavioural Analysis in Wild Type, BDNF+/- and BDNF-/- Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. International Journal of Molecular Sciences. 23(10)
- Wang, L., Ma, J., Wu, W., Fang, Y., Liu, F., Yang, Q., Hu, X., Gu, X., He, Z., Sun, D., Jin, L., Zhang, X. (2022) Effect of aerobic exercise as a treatment on type 2 diabetes mellitus with depression-like behavior zebrafish. Life sciences. 300:120578
- Desvignes, T., Sydes, J., Montfort, J., Bobe, J., Postlethwait, J.H. (2021) Evolution after whole genome duplication: teleost microRNAs. Molecular Biology and Evolution. 38(8):3308-3331
- Evsiukova, V.S., Bazovkina, D., Bazhenova, E., Kulikova, E.A., Kulikov, A.V. (2021) Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 22(23):
- Barbereau, C., Yehya, A., Silhol, M., Cubedo, N., Verdier, J.M., Maurice, T., Rossel, M. (2020) Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological research. 158:104865
- Bhattarai, P., Cosacak, M.I., Mashkaryan, V., Demir, S., Popova, S.D., Govindarajan, N., Brandt, K., Zhang, Y., Chang, W., Ampatzis, K., Kizil, C. (2020) Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS Biology. 18:e3000585
- Hahn, K., Manuel, P., Bouldin, C. (2020) Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish. PeerJ. 8:e10479
- Kedra, M., Banasiak, K., Kisielewska, K., Wolinska-Niziol, L., Jaworski, J., Zmorzynska, J. (2020) TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex. Proceedings of the National Academy of Sciences of the United States of America. 117(4):2170-2179
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Sahu, M.P., Pazos-Boubeta, Y., Pajanoja, C., Rozov, S., Panula, P., Castrén, E. (2019) Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish. Scientific Reports. 9:2036
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