FIGURE

Fig. S7

ID

ZDB-FIG-170706-29

Publication

Pei et al., 2016 - Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases

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Fig. S7

Inhibition on purine synthesis by mycophenolate mofetil partially phenocopies the prps1a:prps1b mutant phenotypes.

(A) Mycophenolate mofetil (MPA) treatment of wild-type embryos causes a reduction in melanocytes and eye size. Arrows point to small eye and melanocyte reduction in MPA-treated embryo. (B) Quantification of eye size reduction. Eye size was measured by Image J. There is a significant reduction of eye size in MPA-treated embryos (t-test, p<0.001). (C) Reduced neuromast hair cells in the treated embryos (t-test, p<0.001). Eye area and neuromast hair cell analysis were performed with 10 embryos for each group. Graphs show the mean and s. e. m.. The data shown were replicated in an additional independent experiment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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