FIGURE

Fig. S4

ID

ZDB-FIG-170512-42

Publication

Keightley et al., 2017 - The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

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Fig. S4

Zbtb11 is dispensable for primitive macrophage development but is required for maintenance of macrophage populations in definitive haemopoiesis (supports Fig. 3h)

a. Macrophages are ablated after 11 h treatment with metronidazole (t=0 hpt);

b. Macrophage repopulation occurs in both control and zbtb11 morphants;

c. Neutrophils in the same animals and conditions as for a are unaffected by macrophage ablation (n=3 experiments; mean ±SEM);

d. Macrophages are depleted in mne at 72-96 hpf (n=3 experiments; each point represents an embryo; pooled data with embryos from individual experiments shown in different colours; 72 hpf, n=32,29; 96 hpf, n=41,38; mean ±SEM; Mann-Whitney test); panels a, b scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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